09:00 Registration (with Coffee & Tea)

10:00 Opening

10:10 Plenary Session
Session 1: Keynote Lecture
Chairs: Aleksandra Badura (Rotterdam) & Chun-Xia Yi (Amsterdam)
Margaret  McCarthy  (Baltimore, MD, USA) Power Play: How Steroids, Endocannabinoids and Behavior Sculpt Neural Development. (45')

11:10 Coffee & Tea

11:30 Parallel Sessions A
Session 2: Illuminating endocannabinoid action in neural circuits
Chairs: Daan van der Vliet (Rotterdam) & Tom van der Wel (Leiden)
Istvan  Katona  (Bloomington, IN, USA) Tba (30')
Jeroen Punt  (Leiden) Bioorthogonal probes to visualize endocannabinoids and their metabolism   (20')
Corette Wierenga  (Nijmegen) Endocannabinoids as mediators of local coordination of excitatory and inhibitory synapses
  (20')
Sylvie Lesuis  (Amsterdam) Stress-induced memory overgeneralization: The central role of endocannabinoid signaling (20')

Session 3: Building and leveraging large-scale single-cell censuses for neuroscience
Chairs: Vanessa Donega (Amsterdam) & Kimberly Siletti (Utrecht)
Rebecca Hodge  (Seattle, WA, USA) Charting the cellular architecture of the human and non-human primate brain (30')
Christiaan de Kock  (Amsterdam) Divergent Transcriptomic and Functional aging of Molecularly Defined Neuron Types in Human Brain (15')
Eileen Brouwer  (Utrecht) Cellular underpinnings of eating disorders (15')
Bart Eggen  (Groningen) The human CNS from a spatial perspective (15')
Aletta van den Bosch  (Milan, Italy) Microglial states associate with lesion dynamics in multiple sclerosis (15')

Session 4: Glial regulation of neuronal activity and synaptic plasticity
Chairs: Nicky Scheefhals & Lot de Witte (Nijmegen)
Marta Navarette  (Madrid, Spain) ASTROENGRAMS: Discovering the Power of Activated Astrocyte Ensembles in Learning and Memory (30')
Mark Verheijen  (Amsterdam) Astrocyte-Synapse Structural Plasticity in Memory Function (15')
Bas Lendemeijer  (Rotterdam) In vitro models to study human glial-neuronal interactions (15')
Carlos González Jimémez  (Nijmegen) Microglial contributions to neural network dysfunction in Kleefstra Syndrome (15')
Nicky Scheefhals  (Nijmegen) Better together: neuron-glia interactions shape synaptic maturation and plasticity in human iPSC-derived networks (15')

Session 5: Beyond neurotransmission: Serotonin's role in brain development across species
Chairs: Judith Homberg & Sharon Kolk (Nijmegen)
Francesca Calabrese  (Milan, Italy) Modulating the serotonergic system across generations: from mother to pup (30')
Marta Samine  (Nijmegen) From neurodevelopment to behavior: impact of lifelong serotonergic dysregulation on prefrontal circuit maturation (15')
Hannah El Marroun  (Rotterdam) Serotonin pathway-specific polygenic risk for psychiatric disorders and brain morphology in adolescents (15')
Judith Homberg  (Nijmegen) Effect of maternal serotonergic genotype on offspring brain and behavioral development (15')
Jocelien Olivier  (Groningen) The effects of cumulative early life stress on anxiety levels in male and female serotonin transporter knockout rats (15')

Session 6: Development and modulation of hippocampal circuits
Chairs: Suzanne van der Veldt (Groningen) & Freyja Ólafsdóttir (Nijmegen)
Andrew MacAskill  (London, United Kingdom) Early life experience shapes hippocampal circuits for learning hidden rules (30')
Guido Meijer  (Nijmegen) Same place, different context: dynamic switching between stimulus-outcome associations by the para-hippocampal network (15')
Guillaume Etter  (Groningen) The preconfigured brain: How internal hippocampal sequences organize adult learning and memory (15')
Freyja Ólafsdóttir  (Nijmegen) What can development tell us about the neuronal underpinnings of spatial memory? (15')
Suzanne van der Veldt  (Groningen) Neuromodulatory tuning of hippocampal activity shapes defensive behavior (15')

Session 7: Multi-domain lifestyle approaches in the prevention and treatment of Alzheimer’s Disease: insights from preclinical and clinical studies
Chairs: Aniko Korosi & Emmy Hoeksema (Amsterdam)
Yvonne Nolan  (Cork, Ireland) Lifestyle factors and the gut-brain axis: relevance to Alzheimer’s (30')
Evgenia Salta  (Amsterdam) Harnessing exercise to amend neuroinflammation in Alzheimer’s disease (15')
Lianne Remie  (Nijmegen) The gut-immune-brain axis in cognitive aging: longitudinal evidence from a multidomain lifestyle intervention in older adults (15')
Yannick Vermeiren  (Wageningen) Mediterranean-style diets and cognitive ageing: modulation of tryptophan metabolism in at-risk older adults (15')
Emmy Hoeksema  (Amsterdam) Omega-3 interventions in Alzheimer’s Disease: where are we at? insights from clinical and preclinical studies (15')

13:00 Lunch

14:15 Parallel Sessions B
Session 8: Synaptic plasticity mechanisms in learning and memory
Chairs: Kubra Gulmez Karaca (Utrecht) & Janina Kupke (Amsterdam)
Alessio Attardo  (Magdeburg, Germany) A new path towards the synaptic engram (30')
Kubra Gulmez Karaca  (Utrecht) Time- and sex-dependent characterization of engram spine morphology in fear memory processing (15')
Janina Kupke  (Amsterdam) The scaffold that remembers: SHANK proteins in memory persistence (15')
Robbert Havekes  (Groningen) Reversing sleep loss-induced spatial and social amnesia (15')
Thije Willems  (Amsterdam) GluA3 mediated synaptic mechanisms for memory consolidation during sleep (15')

Session 9: Voltage-gated ion channels in health and disease
Chairs: Marina Hommersom (Nijmegen) & Else Tolner (Leiden)
Jeffrey Noebels  (Houston, TX, USA) Genes, Currents, Consequences and Correction: The Search for Precision Therapy of Ion Channel Disorders (30')
Maarten Kole  (Amsterdam) Beyond the node: voltage-gated channels and ion flow across the myelin landscape
  (15')
Armagan Kocer  (Enschede) Decoding Dysfunction: How Inherited Mutations Alter Kv4.3 Channel Gating and Lead to Spinocerebellar Ataxia 19/22 (15')
Marina Hommersom  (Nijmegen) Human neuronal networks on micro-electrode arrays as a tool to assess genotype-phenotype correlation in CACNA1A-related disorders (15')
Else Tolner  (Leiden) Linking channelopathy-related mutations to neurophysiological mechanisms in migraine and epilepsy (15')

Session 10: Individual differences in social behaviour and coping across species
Chairs: Rixt van der Veen (Amsterdam) & Michael van der Kooij (Utrecht)
Benjamin Jurek  (Munich, Germany) Observing mice at home: Long-term deep phenotyping of social behavioral traits in a home-cage setting (30')
Jean-Christophe Billeter  (Groningen) Social coping is universal: Modulation of sleep by social experience in Drosophila Melanogaster (15')
Lisa Bouwman  (Amsterdam) Coping is of the essence: Using a complexity approach to integrate different coping behaviors after early life stress (15')
Bart Pollux  (Wageningen) The role of the placenta in transferring maternal stress to developing embryos: a comparison of livebearing fish species with and without placenta (15')
Michael van der Kooij  (Utrecht) Coping early in life: Automated tracking of parental mice gives new directions into the underpinnings of early life stress (15')

Session 11: Innovative iPS cell-derived neuronal models for translational therapy development
Chairs: Katrin Linda (Nijmegen) & Femke de Vrij (Rotterdam)
Aleksandra Pękowska  (Warsaw, Poland) Astrocytes and the evolution of neuronal developmental tempo (30')
Carles Calatayud Aristoy  (Leuven, Belgium) Electrophysiological mapping of human striatal microcircuits enables Parkinson's disease stratification (15')
Katrin Linda  (Nijmegen) Advancing therapeutic insight with human iPS cell-derived neuron–astrocyte models (15')
Dana Vervloet  (Rotterdam) Exploring the potential of antisense oligonucleotide therapy for a RASopathy using iPSC-based models. (15')
Juliette Kamp  (Rotterdam) Investigating the therapeutic potential of SYNGAP1 splice-switching oligonucleotides (15')

Session 12: Metabolic and environmental stressors at the roots of dementia
Chairs: Sébastien Foulquier (Maastricht) & Martina Schmidt (Groningen)
Emma Kasteel  (Utrecht) Plastic not-so-fantastic? Neurotoxic effects of micro- and nanoplastics in vitro (30')
Kenneth Vanbrabant  (Hasselt, Belgium) Early-life air pollution exposure as a driver of later-life cognitive vulnerability (15')
Martina Schmidt  (Groningen) Environmental stressors in experimental Alzheimer models (15')
Amanda Kiliaan  (Nijmegen) Obesity and brain health (15')
Sébastien Foulquier  (Maastricht) Cardiometabolic stressors as drivers of vascular cognitive impairment (15')

Session 13: New crucial roles of neuroglial populations: insight from the glioma-induced changes
Chairs: Lucas Baudouin (Amsterdam) & Marina Trombetta Lima (Groningen)
David Ohayon  (Toulouse, France) Astrocyte heterogeneity and glioblastoma microenvironment (30')
Alexandra de Reus  (Utrecht) The cellular landscape of the glioblastoma invasive front: uncovering mechanisms driving glioblastoma invasion in the tumor micro-environment (15')
Marina Trombetta Lima  (Groningen) Reprogramming the tumor microenvironment through Matrix Metalloproteinase Inhibitors (15')
Frank Kruyt  (Groningen) Identification of novel mechanisms regulating microtube-based cellular connectivity and tumor aggressiveness in glioblastoma (15')
Lucas Baudouin  (Amsterdam) Multiscale analysis of cognitive impairment in IDH-mutant glioma: from connectome to oligodendrocyte dynamics (15')

15:45 Coffee & Tea

16:15 Plenary Session
Session 14: Candida Snow - Take off your culture glasses

17:15 Posters & drinks
Session 15: Poster session 1

18:30 Dinner

20:00 Plenary Session
Session 16: Award Ceremony

21:00 Social

08:30 Registration (with Coffee & Tea)

09:00 Parallel Sessions C
Session 17: How positive and negative early life events shape food intake and related behaviors
Chairs: Frank Meye & Gisela Lazzarino (Utrecht)
Mark Rossi  (New Brunswick, NJ, USA) Rewiring of hypothalamic feeding circuits by early-life overnutrition (30')
Hanneke van Santen  (Utrecht) Acquired hypothalamic dysfunction and its metabolic consequences (15')
Natalia Schilder  (Amsterdam) The effects of oral tributyrin supplementation in a murine, double-hit model of depression
  (15')
Gisela Lazzarino  (Utrecht) How early-life risky play opportunities influence prefrontal cortical circuit function and inhibitory control over food reward seeking (15')

Session 18: Patterns of divergence: Sex effects during brain development from cells to circuits
Chairs: Aleksandra Badura (Rotterdam) & Sam de Kater (Nijmegen)
Gabriele Rune  (Berlin, Germany) Sex-specific regulation of neurosteroid synthesis by GnRH and its relevance for synaptic plasticity in the hippocampus (30')
Lara Wierenga  (Leiden) Understanding vulnerability through variability: a longitudinal twin study linking sex differences in neurodiversity, neurodevelopment and X-linked genetic mechanisms (20')
Anna Sancho Balsells  (Amsterdam) Sex-specific effects of prenatal stress on fetal microglia (15')
Anaïs Notario Reinoso  (Amsterdam) Sex-specific effects of adolescent cannabinoid receptor activation on adult PFC physiology (15')
Sam de Kater  (Nijmegen) Intrinsic properties of CA1 pyramidal cells are set by sex hormones in organotypic hippocampal slices from male and female mice (10')

Session 19: Mitochondrial power failure: at the crossroad of environmental exposure and genetic susceptibility in brain pathologies
Chairs: Amalia Dolga & Tingting Chen (Groningen)
Janine de Santos  (Durham, NC, USA) Tba (30')
Tingting Chen  (Groningen) PSEN1 ΔE9 NPC-Derived Extracellular Vesicles Induce Neural and Metabolic Impairments in Brain Organoids (15')
Vedrana Stefanic  (Nijmegen) Abnormal synaptic transmission in mouse brain and human neuronal cell models of mitochondrial disease (15')
Teresa Mitchell-Garcia  (Groningen) Tba (15')
Angelica Sabogal Guaqueta  (Amsterdam) Mitochondrial dysfunction as a mediator of heavy metal neurotoxicity in microglia. (15')

Session 20: How omics studies can tell tales about the AD and FTD brain
Chairs: Sabine Spijker & Roberta Giannelli (Amsterdam)
Ehsan Pishva  (Maastricht) Large-scale multiomics investigation of cortical miRNA changes in Alzheimer's Disease (30')
Roberta Giannelli  (Amsterdam) Multi-omics approach for defining the disease trajectory of FrontoTemporal Dementia (15')
Guus Smit  (Amsterdam) The proteomic profile of Von Economo neurons  (15')
Betty Tijms  (Amsterdam) Alzheimer CSF proteomics biomarker (15')
Lynn van Olst  (Groningen) Alzheimer brain transcriptomics (15')

Session 21: Spike fast, die young? Development, maturation, plasticity, dysfunction and decline of Parvalbumin-positive neurons and their Perineuronal Nets
Chairs: Moritz Negwer & Corette Wierenga (Nijmegen)
Monika Moissidis  (London, United Kingdom) A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons (15')
Moritz Negwer  (Nijmegen) Whole-brain, three-dimensional visualization of parvalbumin neurons and perineuronal nets (15')
Martijn Selten  (London, United Kingdom) Mechanisms of homeostatic regulation in PV interneurons (15')
Ronald van Kesteren  (Amsterdam) Selective interneuron vulnerability in a mouse model of Alzheimer’s disease (15')
Laure Verret  (Toulouse, France) The role of hippocampal parvalbumin neurons in memory deficits and functional recovery in Alzheimer’s models (30')

Session 22: Antisense oligonucleotide therapeutics for brain disorders
Chairs: Ronald Buijsen (Leiden) & Dana Vervloet (Rotterdam)
Ype Elgersma  (Rotterdam) Developing Antisense Oligonucleotide (ASO) therapy for Neuordevelopmental Disorders: From proof of concept to clinical trials (30')
Ronald Buijsen  (Leiden) How to synthesize ASOs? (15')
Linde Bouwman  (Leiden) How to start designing ASOs for pre-clinical development (15')
Inge Zuhorn  (Groningen) Cellular Processing of Delivery Vehicles (15')
Marjon Pasmooij  (Utrecht) Regulatory aspects of ASO therapeutics (15')

10:30 Coffee & Tea

11:00 Parallel Sessions D
Session 23: Synaptic and network alterations in early Alzheimer's disease
Chairs: Lucas Lumeij & Ronald van Kesteren (Amsterdam)
Stefan Remy  (Magdeburg, Germany) Synaptic and network dysfunction in Alzheimer's disease (30')
Zehra Kazmi  (Amsterdam / Nijmegen) Excitatory targets, inhibitory consequences: How amyloid-β oligomers tip the scales of network E/I balance during early Alzheimer’s disease (15')
Lucas Lumeij  (Amsterdam) The role of AMPA receptor subunit GluA3 in amyloid-β-induced synaptic and network alterations in Alzheimer's disease (15')
Kevin Marinus  (Amsterdam) Alzheimer-causing PSEN1 mutations interfere with early neuronal differentiation in a human iPSC-derived model for neurodevelopment (15')
Anne van Nifterick  (Amsterdam) Unravelling hyperexcitability in Alzheimer's disease: towards non-invasive network markers  (15')

Session 24: Intrinsic plasticity: shaping signals from input through output to circuits
Chairs: Ting-Feng Lin (Utrecht) & Maarten Kole (Amsterdam)
Guillaume Drion  (Liège, Belgium) How spiking-to-bursting transitions shape network functional and structural connectivity (30')
Zahra Hemmat  (Rotterdam) Cerebellar subpopulation-specific differences in intrinsic excitability and plasticity related to distinct movement kinematics (15')
Roberto D’Angelo  (Utrecht) Prefrontal Cortical Plasticity in the regulation of Binge Behavior (15')
Vasiliki Theodorou  (Amsterdam) Chronic network silencing triggers distinct AIS plasticity in excitatory and inhibitory neurons (15')
Ting-Feng Lin  (Utrecht) Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum (15')

Session 25: Human in vitro and primary tissue models of brain development and disease
Chairs: Steven Sloan (Amsterdam) & Noelia Anton Bolanos (Utrecht)
Debby Silver  (Durham, NC, USA) Building our brains: from development to evolution (30')
Noelia Anton Bolanos  (Utrecht) Mirroring human Brain Development and Disease using Brain Organoids as Avatars (15')
Femke de Vrij  (Rotterdam) Disease modeling using human adherent cortical organoids  (15')
Anna Pagliaro  (Utrecht) Deciphering mechanisms driving human brain development and expansion: insights from novel in vitro organoid systems (15')
Evgenia Salta  (Amsterdam) Single-cell molecular mapping of human adult hippocampal neurogenesis in Alzheimer’s disease and resilience
  (15')

Session 26: Neuromorphic computing
Chairs: Arezoo Alizadeh (Nijmegen) & Mario Negrello (Rotterdam)
Herbert Jaeger  (Groningen) A semantic theory of universal computation - why? therefore! (30')
Federico Corradi  (Eindhoven) Why Backpropagation Will Fade and Spikes Will Learn: Toward Local Learning in Spiking Neural Networks (15')
Chiara De Luca  (Zurich, Switzerland) Abstract: Neuromorphic digital twins for closed-loop neurostimulation (15')
Tim Kamsma  (Utrecht) Brain-inspired computing in a brain-inspired medium (15')
Arezoo Alizadeh  (Nijmegen) Space-By-Time Semi-NMF: A Decomposition Approach for Single-Trial Neural Decoding (15')

Session 27: Expanding dimensions of cAMP signaling: from spatial nanodomains to cell-wide integration
Chairs: Melissa Schepers (Diepenbeek, Belgium) & Tim Vanmierlo (Hasselt, Belgium)
Cécile Derieux  (Mainz, Germany) cAMP nanodomains and GPCR signaling (30')
Rosa Randoe  (Amsterdam) GPCR signaling at astrocyte endfeet: GPRC5B and the biology of brain edema (15')
Martina Schmidt  (Groningen) The Role of cAMP in Neurodegenerative Models (Eng) (15')
Rob Leurs  (Amsterdam) GPCR pharmacology and ligand-receptor mechanisms (15')
Tim Vanmierlo  (Hasselt, Belgium) cAMP signaling in myelination (15')

Session 28: Adaptive forgetting mechanisms: translational approaches across neuroscience disciplines
Chairs: Conny Quaedflieg (Maastricht) & Kevin van Schie (Tilburg)
Michael Anderson  (Cambridge, United Kingdom) Cognitive and neurobiological mechanisms supporting intentional forgetting (30')
Martyna Gwiazda  (Maastricht) Intentional suppression of memories consolidated under stress (20')
Ralph Wientjens  (Amsterdam) Memory suppression versus Extinction: disentangling effects on memory content and emotional affect (20')
Kevin van Schie  (Tilburg) Non-invasive brain stimulation to enhance individuals’ capacity to control intrusive memories (20')

12:30 Lunch

13:45 Plenary Session
Session 29: Keynote Lecture
Chair: Conny Quaedflieg (Maastricht)
Michael Anderson  (Cambridge, United Kingdom) TBA (45')

14:45 Coffee & Tea

15:15 Parallel Sessions E
Session 30: Rebalancing Neuroscience: Revealing sex-dependent mechanisms in health and disease
Chairs: Sabine Spijker & Sophie van der Sluis (Amsterdam)
Sofie Valk  (Düsseldorf, Germany) Tba (30')
Anne Marije Kaag  (Amsterdam) Connectomics, drugs of abuse (15')
Cato Romero  (Amsterdam) Sex differences in genetic pathways underlying ischaemic heart disease–depression comorbidity (15')
Lin Zhang  (Amsterdam) Sex differences in the cholinergic system in depression and suicide (15')
Sabine Spijker  (Amsterdam) Diversity in depression-induced proteomic signatures (15')

Session 31: Dynamics of blood vessels in the maturing brain: mechanisms of formation, repair and communication with neurons.
Chairs: Carla Gomes da Silva (Utrecht) & Amparo Acker Palmer (Frankfurt)
Amparo Acker Palmer  (Frankfurt) Tba (30')
Carlos Flores Clara  (Utrecht) New mechanisms of glia-mediated vascular repair during brain development (20')
Henrique Nogueira Pinto  (Amsterdam) From stem cells to neurovascular networks: Building a functional human blood-brain barrier in vitro (20')
Tommaso Ristori  (Eindhoven) Integrating experiments with simulations to unravel pathological angiogenesis (20')

Session 32: Shared and distinct mechanisms in synucleopathies and tauopathies: synergistic to solutions  
Chairs: Wiep Scheper & Wilma van de Berg (Amsterdam)
Wiep Scheper  (Amsterdam) Neuronal resilience to tau and α-synuclein pathology: shared mechanisms and opportunities (15')
Marcel Verbeek  (Nijmegen) What body fluid biomarkers can tell learn us about overlap and differences in neurodegenerative disorders (15')
Wilma van de Berg  (Amsterdam) Tba (15')
Bart Eggen  (Groningen) Tba (15')
Panel discussion with the speakers incl. questions from the audience (30')

Session 33: Modeling iPSC-Microglia: insights & communication (MIMIC-NL)
Chairs: Lot de Witte (Nijmegen) & Amalia Dolga (Groningen)
Sarka Lehtonen  (Kuopio) Multiscale Modeling of Human Microglia in Synucleinopathies: From Cellular States to Organoid and In Vivo Neurodegeneration (30')
Lot de Witte  (Nijmegen) Tba (15')
Renata Baptista Vieira de Sa  (Amsterdam) Microglia cause HIV-induced transcriptional and metabolic changes in human neural organoids (15')
Kim Kleijn  (Amsterdam) iPSC-derived microglial interferon states in drug screening for Alzheimer’s disease (15')
Amalia Dolga  (Groningen) Tba (15')

Session 34: The Locus Coeruleus across states: noradrenergic modulation from synapses to behavior
Chairs: Danai Riga & Helmut Kessels (Amsterdam)
Jordan McCall  (St. Louis, MO, USA) Parsing pain and aversion in the locus coeruleus noradrenergic system (30')
Helmut Kessels  (Amsterdam) Effects of noradrenaline signaling on synaptic plasticity (15')
Danai Riga  (Amsterdam) Deciphering the neural footprints of physical and emotional adversity (15')
Alejandro Osorio-Forero  (Amsterdam) Sleep in translation: hyperarousal in rodent and human sleep (15')
Lukas van Herk  (Utrecht) Acute stress in humans: military decision-making (15')

Session 35: Integrative computational neuroscience: from deep learning to spikeing and data-driven approaches
Chairs: Ellen Boven & Zhenyu Gao (Rotterdam)
Loreen Hertäg  (Berlin, Germany) Modelling prediction errors: from neurons to circuits to cortical layers (30')
Jorge Mejías  (Amsterdam) Biological architectures for predictive coding (15')
Heike Stein  (Paris, France) Reconstructing the dynamics of locomotion explains the emergence of coordinated gaits on structured surfaces in mice (15')
Fleur Zeldenrust  (Nijmegen) Heterogeneity in the brain: lessons from theory and experiment
 (15')
Pedro Gonçalves  (Leuven, Belgium) Machine learning for mechanistic insight in neuroscience (15')

16:45 Posters & drinks
Session 36: Poster session 2

18:00 Closure DNM 26 & poster prizes